Kessai H. Note was born on 7 August 1950 at Airok on Ailinglaplap Atoll in the central Marshall Islands. He graduated from Marshall Islands High School and received a degree in agriculture from Vudal College in Papua New Guinea. He entered public service the same year, taking a position as an agricultural economist with the Division of Agriculture.
Note was active in the Marshall Islands' drive for independence between 1976 and 1979, and has played a prominent role in government in the two decades since independence was achieved. In addition to serving in the Parliament and cabinet, he has been a key player at the nation's constitutional conventions, as well as serving on the boards of the Marshall Islands Community Action Agency and the National Telecommunications Authority, and on the Foreign Investment Board. He has also served as president of the Marshall Islands Sport Council and vice chairman of the board of Air Marshall Islands.
Note is married to Mary Neimoj Yamamura and has five children. Among his hobbies are fishing, tennis, and gardening.